The Evolutionary Pattern and the Regulation of Stearoyl-CoA Desaturase Genes

The Evolutionary Pattern and the Regulation of Stearoyl-CoA Desaturase Genes

Stearoyl-CoA desaturase (SCD) is a key enzyme that converts saturated fatty acids (SFAs) to monounsaturated fatty acids (MUFAs) in the biosynthesis of fat. To date, two isoforms of scd gene (scd1 and scd5) have been found widely existent in most of the vertebrate animals. However, the evolutionary patterns of both isofoms and the function of scd5 are poorly understandable. Herein, we aim to cha...

An Evolutionary Relationship Between Stearoyl-CoA Desaturase (SCD) Protein Sequences Involved in Fatty Acid Metabolism

Background: Stearoyl-CoA desaturase (SCD) is a key enzyme that converts saturated fatty acids (SFAs) to monounsaturated fatty acids (MUFAs) in fat biosynthesis. Despite being crucial for interpreting SCDs’ roles across species, the evolutionary relationship of SCD proteins across species has yet to be elucidated. This study aims to present this evolutionary relationship based on amino aci...

The regulation of lipid droplet size and phospholipid composition by stearoyl-CoA desaturase

Characterization and regulation of the bovine stearoyl-CoA desaturase gene promoter.

The bovine stearoyl-CoA desaturase (Scd) gene plays an important role in the bovine mammary gland where substrates such as stearic and vaccenic acids are converted to oleic acid and conjugated linoleic acid (CLA), respectively. Up to 90% of the CLA in bovine milk is formed due to the action of this enzyme in the mammary gland. The areas of the bovine promoter of importance in regulating this ke...

Expression and Nutritional Regulation of Stearoyl-CoA Desaturase Genes in the Ruminant Mammary Gland: Relationship with Milk Fatty Acid Composition

In lactating ruminants, stearoyl-CoA desaturase ( SCD ) gene expression in the mammary gland focused particular attention due to its implication in milk technological and nutritional qualities for human consumers. Indeed, the mammary enzyme SCD or ∆9-desaturase by introducing a cis double bond between carbons 9 and 10 of the fatty acids (FA) has a key role in the synthesis of milk monounsaturat...